GAS1 and SHH

Data Source:
HPRD (in vitro, in vivo)

		GAS1	SHH
Description		growth arrest specific 1	sonic hedgehog signaling molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Raft Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Patched Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Peptidase Activity Zinc Ion Binding Morphogen Activity Laminin-1 Binding
	Biological Process	Cell Cycle Arrest Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of ER To Golgi Vesicle-mediated Transport	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Osteoblast Development Lymphoid Progenitor Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Endocytosis Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Cell-cell Signaling Pattern Specification Process Ectoderm Development Neuroblast Proliferation Axon Guidance Central Nervous System Development Ventral Midline Development Hindgut Morphogenesis Heart Development Blood Coagulation Androgen Metabolic Process Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Polarity Specification Of Anterior/posterior Axis Dorsal/ventral Pattern Formation Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Cell Proliferation Myotube Differentiation Intein-mediated Protein Splicing Protein Autoprocessing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Thalamus Development Dorsal/ventral Neural Tube Patterning Cerebellar Granule Cell Precursor Proliferation Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Telencephalon Regionalization Establishment Of Cell Polarity Regulation Of Proteolysis Positive Regulation Of Wnt Signaling Pathway Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Male Genitalia Development Prostate Gland Development Thyroid Gland Development Forebrain Development Midbrain Development Hindbrain Development Pancreas Development Hair Follicle Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Thymic T Cell Selection Negative Thymic T Cell Selection Intermediate Filament Organization Myoblast Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Cell Development Thymus Development Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Animal Organ Formation Neuron Fate Commitment Embryonic Skeletal System Development Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Formation Of Anatomical Boundary Stem Cell Development Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division Bergmann Glial Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Limb Bud Formation Lung Epithelium Development Trachea Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Right Lung Development Left Lung Development Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Primary Prostatic Bud Elongation Prostate Epithelial Cord Elongation Salivary Gland Cavitation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Prostatic Bud Formation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Artery Development Mesenchymal Cell Proliferation Involved In Lung Development Somite Development Positive Regulation Of Sclerotome Development Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Apoptotic Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Protein Localization To Nucleus Negative Regulation Of Dopaminergic Neuron Differentiation Tracheoesophageal Septum Formation Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Ligand-receptor interactions Activation of SMO	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Holoprosencephaly (HPE) Basal cell carcinoma Solitary median maxillary central incisor syndrome
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Corneal astigmatism ( 23322567) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Macular thickness ( 30535121) Platelet aggregation ( 20526338 29185836)
Interacting Genes		4 interacting genes: BIRC2 DLK1 ERRFI1 SHH	5 interacting genes: ADCYAP1 GAS1 HHIP PTCH1 PTCH2
Entrez ID		2619	6469
HPRD ID		00747	02838
Ensembl ID		ENSG00000180447	ENSG00000164690
Uniprot IDs		P54826	Q15465
PDB IDs			3HO5 3M1N 3MXW 6DMY 6E1H 6N7G 6N7H 6N7K 6OEV 6PJV 6RMG 6RVD
Enriched GO Terms of Interacting Partners?
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