SIGLEC5 and SLC7A8

Data Source:
BioGRID (two hybrid)

		SIGLEC5	SLC7A8
Description		sialic acid binding Ig like lectin 5	solute carrier family 7 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding	Protein Binding Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Peptide Antigen Binding
	Biological Process	Cell Adhesion Neutrophil Degranulation	Amino Acid Transmembrane Transport Amino Acid Transport Response To Toxic Substance Organic Cation Transport Neutral Amino Acid Transport Glycine Transport Leucine Transport Tryptophan Transport Valine Transport Proline Transmembrane Transport Leukocyte Migration Metal Ion Homeostasis Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Leucine Import Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Basigin interactions Amino acid transport across the plasma membrane
Drugs			Phenylalanine Alanine
Diseases
GWAS		Aggressive periodontitis ( 28449029) Blood protein levels ( 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Leprosy ( 25642632) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Periodontitis ( 30218097) Platelet distribution width ( 32888494)
Interacting Genes		5 interacting genes: LGALS3BP NAPB SLC7A8 TRIP13 VAC14	26 interacting genes: ABHD16A AGPAT4 AQP6 COMT DERL1 FXYD6-FXYD2 MFF MFSD3 NDUFA3 NINJ2 REEP4 SIGLEC5 SLC25A46 SLC30A2 SLC3A1 SLC3A2 SMPD2 SNORC SYCE1L SYNJ2BP TMEM14B TMEM208 TMEM60 TMEM65 YIPF1 YIPF6
Entrez ID		8778	23428
HPRD ID		05011	11971
Ensembl ID		ENSG00000105501	ENSG00000092068
Uniprot IDs		O15389	Q53EM9 Q9UHI5
PDB IDs		2ZG1 2ZG2 2ZG3
Enriched GO Terms of Interacting Partners?
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