HRK and CBR1

Data Source:
BioGRID (two hybrid)

		HRK	CBR1
Description		harakiri, BCL2 interacting protein	carbonyl reductase 1
Image
GO Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane	Cytosol Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding	Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin-E2 9-reductase Activity
	Biological Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Drug Metabolic Process Cyclooxygenase Pathway Epithelial Cell Differentiation Vitamin K Metabolic Process
Pathways			Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)
Interacting Genes		7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	7 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B PTPRF UBC VHL
Entrez ID		8739	873
HPRD ID		04581	00267
Ensembl ID		ENSG00000135116	ENSG00000159228
Uniprot IDs		O00198	A0A384NL53 P16152
PDB IDs		2L58 2L5B 6XY4	1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
Enriched GO Terms of Interacting Partners?
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