CBR1 and HTR2B

Data Source:
BioGRID (two hybrid)

		CBR1	HTR2B
Description		carbonyl reductase 1	5-hydroxytryptamine receptor 2B
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome Extracellular Vesicle	Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin-E2 9-reductase Activity	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding
	Biological Process	Drug Metabolic Process Cyclooxygenase Pathway Epithelial Cell Differentiation Vitamin K Metabolic Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Embryonic Morphogenesis Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Serotonin receptors G alpha (q) signalling events
Drugs		Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate	Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)	Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		7 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B PTPRF UBC VHL	27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1
Entrez ID		873	3357
HPRD ID		00267	03077
Ensembl ID		ENSG00000159228	ENSG00000135914
Uniprot IDs		A0A384NL53 P16152	P41595
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D	4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0
Enriched GO Terms of Interacting Partners?
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