CBR1 and HRK

Data Source:
BioGRID (two hybrid)

		CBR1	HRK
Description		carbonyl reductase 1	harakiri, BCL2 interacting protein
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome Extracellular Vesicle	Mitochondrion Integral Component Of Membrane
	Molecular Function	Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin-E2 9-reductase Activity	Protein Binding
	Biological Process	Drug Metabolic Process Cyclooxygenase Pathway Epithelial Cell Differentiation Vitamin K Metabolic Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)	Alzheimer's disease (age of onset) ( 22005931) Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)
Interacting Genes		7 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B PTPRF UBC VHL	7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1
Entrez ID		873	8739
HPRD ID		00267	04581
Ensembl ID		ENSG00000159228	ENSG00000135116
Uniprot IDs		A0A384NL53 P16152	O00198
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D	2L58 2L5B 6XY4
Enriched GO Terms of Interacting Partners?
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