EIF4G3 and MKNK1

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		EIF4G3	MKNK1
Description		eukaryotic translation initiation factor 4 gamma 3	MAPK interacting serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Translation Factor Activity, RNA Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		ISG15 antiviral mechanism	Spry regulation of FGF signaling
Drugs			Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Red blood cell count ( 32888494) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)	Schizophrenia ( 26198764) Triglyceride levels ( 31170924)
Interacting Genes		8 interacting genes: CAMK1 EIF4A1 EIF4E HSPB1 LIG4 MKNK1 PABPC1 VAV2	26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		8672	8569
HPRD ID		06802	09468
Ensembl ID		ENSG00000075151	ENSG00000079277
Uniprot IDs		A0A0A0MSA7 O43432 Q59GJ0	A8K341 Q7Z319 Q9BUB5
PDB IDs		1HU3	2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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