EIF4G3 and CAMK1

Data Source:
HPRD (in vitro, in vivo)

		EIF4G3	CAMK1
Description		eukaryotic translation initiation factor 4 gamma 3	calcium/calmodulin dependent protein kinase I
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Intracellular Anatomical Structure Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Translation Factor Activity, RNA Binding	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation
Pathways		ISG15 antiviral mechanism	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs			Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Red blood cell count ( 32888494) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		8 interacting genes: CAMK1 EIF4A1 EIF4E HSPB1 LIG4 MKNK1 PABPC1 VAV2	22 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		8672	8536
HPRD ID		06802	05412
Ensembl ID		ENSG00000075151	ENSG00000134072
Uniprot IDs		A0A0A0MSA7 O43432 Q59GJ0	B0YIY3 Q14012
PDB IDs		1HU3	4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?
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