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EIF3J and METTL3
Data Source:
BioGRID
(pull down)
EIF3J
METTL3
Description
eukaryotic translation initiation factor 3 subunit J
methyltransferase like 3
Image
GO Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Eukaryotic 43S Preinitiation Complex
Eukaryotic 48S Preinitiation Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
RNA N6-methyladenosine Methyltransferase Complex
Molecular Function
Translation Initiation Factor Activity
Protein Binding
Identical Protein Binding
MRNA (N6-adenosine)-methyltransferase Activity
MRNA Binding
Protein Binding
Methyltransferase Activity
RNA Methyltransferase Activity
MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity
Protein Heterodimerization Activity
S-adenosyl-L-methionine Binding
Biological Process
Formation Of Cytoplasmic Translation Initiation Complex
Translational Initiation
MRNA Splicing, Via Spliceosome
RNA Methylation
Adenosine To Inosine Editing
MRNA Processing
MRNA Catabolic Process
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Circadian Rhythm
Dosage Compensation By Inactivation Of X Chromosome
RNA Metabolic Process
Stem Cell Population Maintenance
Forebrain Radial Glial Cell Differentiation
Primary MiRNA Processing
Cellular Response To UV
Gliogenesis
Innate Immune Response
Regulation Of T Cell Differentiation
Positive Regulation Of Translation
Negative Regulation Of Notch Signaling Pathway
Regulation Of Meiotic Cell Cycle
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
MRNA Destabilization
MRNA Methylation
Endothelial To Hematopoietic Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Cap-independent Translational Initiation
Primary MiRNA Methylation
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS
Anti-Toxoplasma gondii IgG seropositivity (
30610941
)
Response to Homoharringtonine (cytotoxicity) (
25628645
)
Interacting Genes
15 interacting genes:
ABCE1
CASP3
CSNK2A1
EIF3A
EIF3B
EIF3C
EIF3D
EIF3K
GNB5
GOLM1
MAGED1
METTL3
SIAH1
TADA3
TPD52L1
5 interacting genes:
EIF3G
EIF3I
EIF3J
EIF3M
MTDH
Entrez ID
8669
56339
HPRD ID
04883
14389
Ensembl ID
ENSG00000104131
ENSG00000165819
Uniprot IDs
A0A024R5S5
O75822
Q86U44
PDB IDs
2KRB
3BPJ
6YBW
6ZMW
6ZVJ
5IL0
5IL1
5IL2
5K7M
5K7U
5K7W
5L6D
5L6E
5TEY
5YZ9
6TTP
6TTT
6TTV
6TTW
6TTX
6TU1
6Y4G
7ACD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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