EIF3C and DOC2A

Data Source:
BioGRID (genetic interference)

		EIF3C	DOC2A
Description		eukaryotic translation initiation factor 3 subunit C	double C2 domain alpha
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleoplasm Nucleolus Lysosome Cell Junction Neuron Projection Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding	Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		19 interacting genes: AAGAB ALKBH4 CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 NDUFA4L2 PFDN1 PLEKHF2 RPS6KA3 SMAD9 SNIP1 TACC3 TRAPPC2	5 interacting genes: DYNLT1 RAP1GDS1 STXBP1 UBASH3B UNC13B
Entrez ID		8663	8448
HPRD ID		04889	05195
Ensembl ID		ENSG00000184110	ENSG00000149927
Uniprot IDs		A0A024QYU9 Q99613	Q14183
PDB IDs		3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09	4MJJ
Enriched GO Terms of Interacting Partners?
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