EIF3B and TBC1D23

Data Source:
BioGRID (two hybrid)

		EIF3B	TBC1D23
Description		eukaryotic translation initiation factor 3 subunit B	TBC1 domain family member 23
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle WASH Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Brain Development Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Vesicle Tethering To Golgi Embryonic Brain Development
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
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Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)	Axial length ( 24144296) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		18 interacting genes: BHLHB9 BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1	12 interacting genes: CAGE1 EHD2 EIF3B FAM214B KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-12 NOPCHAP1 SSBP3 STK11 WDR62
Entrez ID		8662	55773
HPRD ID		06795	07727
Ensembl ID		ENSG00000106263	ENSG00000036054
Uniprot IDs		A0A024R821 A4D210 P55884	Q9NUY8
PDB IDs		2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09	6JL7 6JM5
Enriched GO Terms of Interacting Partners?
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