EIF3A and RNF139

Data Source:
BioGRID (pull down)

		EIF3A	RNF139
Description		eukaryotic translation initiation factor 3 subunit A	ring finger protein 139
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translation Reinitiation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Phosphopantetheinylation Protein Destabilization ERAD Pathway Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Plateletcrit ( 32888494)
Interacting Genes		22 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF139 SRPK2 TFIP11 UBC UPF1 YWHAZ	6 interacting genes: COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		8661	11236
HPRD ID		03618	04333
Ensembl ID		ENSG00000107581	ENSG00000170881
Uniprot IDs		Q14152	Q8WU17
PDB IDs		3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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