PDE5A and PRKG1

Data Source:
HPRD (in vitro)

		PDE5A	PRKG1
Description		phosphodiesterase 5A	protein kinase cGMP-dependent 1
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GO Annotations	Cellular Component	Cellular_component Cytosol	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Signal Transduction CGMP Catabolic Process	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		cGMP effects	Ca2+ pathway
Drugs		Caffeine Caffeine Sildenafil Theophylline Tadalafil Vardenafil Dipyridamole Guanosine-5'-Monophosphate gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine OSI-461 Avanafil Exisulind Udenafil 3-isobutyl-1-methyl-7H-xanthine 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide Trapidil Fostamatinib
Diseases
GWAS		Coronary artery disease ( 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		3 interacting genes: CASP3 PRKG1 SPG21	39 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP WDR77 ZNF646
Entrez ID		8654	5592
HPRD ID		04497	08910
Ensembl ID		ENSG00000138735	ENSG00000185532
Uniprot IDs		G5E9C5 O76074	Q13976
PDB IDs		1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 4G2W 4G2Y 4I9Z 4IA0 4MD6 4OEW 4OEX 5JO3 5ZZ2 6ACB 6IWI 6L6E	1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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