PDE5A

Description		phosphodiesterase 5A
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GO Annotations	Cellular Component	Cellular_component Cytosol
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction CGMP Catabolic Process
Pathways		cGMP effects
Drugs		Caffeine Caffeine Sildenafil Theophylline Tadalafil Vardenafil Dipyridamole Guanosine-5'-Monophosphate gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine OSI-461 Avanafil Exisulind Udenafil 3-isobutyl-1-methyl-7H-xanthine 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide Trapidil Fostamatinib
Diseases
GWAS		Coronary artery disease ( 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		3 interacting genes: CASP3 PRKG1 SPG21
Entrez ID		8654
HPRD ID		04497
Ensembl ID		ENSG00000138735
Uniprot IDs		G5E9C5 O76074
PDB IDs		1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 4G2W 4G2Y 4I9Z 4IA0 4MD6 4OEW 4OEX 5JO3 5ZZ2 6ACB 6IWI 6L6E
Enriched GO Terms of Interacting Partners?
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