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CBFB and RUNX2
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
CBFB
RUNX2
Description
core-binding factor subunit beta
RUNX family transcription factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Membrane
Core-binding Factor Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Transcription Coactivator Activity
Protein Binding
Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
ATP Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Osteoblast Differentiation
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Lymphocyte Differentiation
Myeloid Cell Differentiation
Regulation Of Wnt Signaling Pathway
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
Regulation Of Keratinocyte Differentiation
Regulation Of Myeloid Cell Differentiation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Regulation Of B Cell Receptor Signaling Pathway
Definitive Hemopoiesis
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Bicellular Tight Junction Assembly
Ossification
Osteoblast Differentiation
Chondrocyte Differentiation
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Hemopoiesis
Neuron Differentiation
BMP Signaling Pathway
Regulation Of Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Transcriptional regulation by RUNX2
Transcriptional regulation by RUNX2
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
RUNX1 regulates transcription of genes involved in WNT signaling
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
RUNX2 regulates osteoblast differentiation
RUNX2 regulates osteoblast differentiation
RUNX2 regulates chondrocyte maturation
RUNX2 regulates bone development
RUNX2 regulates genes involved in cell migration
RUNX2 regulates genes involved in cell migration
RUNX2 regulates genes involved in differentiation of myeloid cells
Regulation of RUNX3 expression and activity
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 Regulates Immune Response and Cell Migration
RUNX3 regulates RUNX1-mediated transcription
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
Drugs
Diseases
Cleidocranial dysplasia
GWAS
Mean corpuscular hemoglobin (
27863252
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
32528159
29760442
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
facial morphology traits (multivariate analysis) (
27193062
)
Gout (normal type) (
32238385
)
Height (
25429064
18391951
)
Hip minimal joint space width (
27701424
)
Hip shape (DXA scan) (
30320955
)
Intraocular pressure (
29785010
30054594
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Lymphocyte percentage of white cells (
32888494
)
Mosquito bite size (
28199695
)
Osteoarthritis (hip) (
30374069
)
Periodontal microbiota (
22699663
)
Progressive supranuclear palsy (
30089514
)
Subcortical volume (MOSTest) (
32665545
)
Survival in pancreatic cancer (
28470677
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
9 interacting genes:
CBFA2T2
CHGB
CHRM5
COPRS
RAB2A
RNF7
RUNX1
RUNX2
RUNX3
37 interacting genes:
ALYREF
AR
AXIN1
CBFB
CCNB1
CDK1
CEBPB
DVL2
EP300
ETS1
FHL2
FOS
HDAC3
HDAC4
HDAC6
HDAC7
HIF1A
HIVEP3
JUN
KAT6B
LEF1
MAP3K4
MSX2
PRKCD
RB1
RBM14
SMAD2
SMAD3
SMAD6
SMURF2
SOX9
STUB1
TAF1A
UBTF
XRCC5
XRCC6
YAP1
Entrez ID
865
860
HPRD ID
00418
02566
Ensembl ID
ENSG00000067955
ENSG00000124813
Uniprot IDs
A0A024R6X2
Q13951
A0A0D9SEN7
Q13950
Q32MY8
PDB IDs
1CL3
1E50
1H9D
4N9F
6NIL
6P59
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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