PTCH2 and IHH

Data Source:
HPRD (in vivo)

		PTCH2	IHH
Description		patched 2	Indian hedgehog signaling molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Space Plasma Membrane Extracellular Matrix
	Molecular Function	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Regulation Of Cell Growth Cell Fate Determination Smoothened Signaling Pathway Epidermal Cell Fate Specification Hair Cycle Skin Development Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway	Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Proteoglycan Metabolic Process Smoothened Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Embryonic Pattern Specification Regulation Of Gene Expression Intein-mediated Protein Splicing Protein Autoprocessing Vitelline Membrane Formation Pancreas Development Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion Liver Regeneration
Pathways		Class B/2 (Secretin family receptors)	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np RUNX2 regulates chondrocyte maturation
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome	Brachydactyly, including: type A; type B; type D; type E Acrocapitofemoral dysplasia
GWAS		Intraocular pressure ( 30591961)	Height ( 20881960 31562340 18391951 18391952 20189936) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		4 interacting genes: DHH IHH SHH SMO	4 interacting genes: HHIP PTCH1 PTCH2 RHOD
Entrez ID		8643	3549
HPRD ID		04722	02839
Ensembl ID		ENSG00000117425	ENSG00000163501
Uniprot IDs		Q9Y6C5	Q14623
PDB IDs			3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
Enriched GO Terms of Interacting Partners?
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