NPFF and NPFFR1

Data Source:
HPRD (in vitro, in vivo)

		NPFF	NPFFR1
Description		neuropeptide FF-amide peptide precursor	neuropeptide FF receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Cilium
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Peptide Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Drug Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Biological_process
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Cognitive decline rate in late mild cognitive impairment ( 26252872) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17	2 interacting genes: NPFF TCP11
Entrez ID		8620	64106
HPRD ID		06869	12120
Ensembl ID		ENSG00000139574	ENSG00000148734
Uniprot IDs		O15130	Q9GZQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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