NPFFR1 and NPFF

Data Source:
HPRD (in vitro, in vivo)

		NPFFR1	NPFF
Description		neuropeptide FF receptor 1	neuropeptide FF-amide peptide precursor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Peptide Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Biological_process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Drug Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Cognitive decline rate in late mild cognitive impairment ( 26252872) Squamous cell lung carcinoma ( 28604730)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: NPFF TCP11	4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17
Entrez ID		64106	8620
HPRD ID		12120	06869
Ensembl ID		ENSG00000148734	ENSG00000139574
Uniprot IDs		Q9GZQ6	O15130
PDB IDs
Enriched GO Terms of Interacting Partners?
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