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RUNX1 and EP300
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro, in vivo)
RUNX1
EP300
Description
RUNX family transcription factor 1
E1A binding protein p300
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Core-binding Factor Complex
Intracellular Membrane-bounded Organelle
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytosol
Protein-DNA Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
ATP Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Transferase Activity, Transferring Acyl Groups
Chromatin DNA Binding
Activating Transcription Factor Binding
Nuclear Hormone Receptor Binding
Tau Protein Binding
Androgen Receptor Binding
NF-kappaB Binding
Peptide-lysine-N-acetyltransferase Activity
Protein Propionyltransferase Activity
Pre-mRNA Intronic Binding
STAT Family Protein Binding
Peptide Butyryltransferase Activity
Histone Crotonyltransferase Activity
Histone Butyryltransferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ossification
Regulation Of Cytokine-mediated Signaling Pathway
Chondrocyte Differentiation
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
Regulation Of Plasminogen Activation
Hemopoiesis
Regulation Of Wnt Signaling Pathway
Neuron Differentiation
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
Regulation Of Cell Differentiation
Regulation Of Keratinocyte Differentiation
Regulation Of Myeloid Cell Differentiation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Peripheral Nervous System Neuron Development
Regulation Of B Cell Receptor Signaling Pathway
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Tissue Regeneration
Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Extracellular Matrix Organization
Regulation Of Connective Tissue Replacement
Regulation Of Bicellular Tight Junction Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Somitogenesis
Thigmotaxis
Behavioral Defense Response
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Glycolytic Process
Transcription-coupled Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Protein Acetylation
Internal Protein Amino Acid Acetylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Learning Or Memory
Circadian Rhythm
Animal Organ Morphogenesis
Regulation Of Autophagy
Macrophage Derived Foam Cell Differentiation
Regulation Of Mitochondrion Organization
Positive Regulation Of Neuron Projection Development
Viral Process
Histone Acetylation
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
B Cell Differentiation
Platelet Formation
Lung Development
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Positive Regulation Of Protein Binding
Positive Regulation Of Type I Interferon Production
Cellular Response To UV
Multicellular Organism Growth
Megakaryocyte Development
Swimming
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To Estrogen
Positive Regulation By Host Of Viral Transcription
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Face Morphogenesis
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Peptidyl-lysine Propionylation
Regulation Of Tubulin Deacetylation
Peptidyl-lysine Crotonylation
Peptidyl-lysine Butyrylation
Regulation Of Cellular Response To Heat
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways
Pre-NOTCH Transcription and Translation
Organic cation transport
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
Regulation of RUNX1 Expression and Activity
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
RUNX1 regulates transcription of genes involved in WNT signaling
RUNX2 regulates genes involved in differentiation of myeloid cells
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
Polo-like kinase mediated events
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
B-WICH complex positively regulates rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NGF-stimulated transcription
NGF-stimulated transcription
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Drugs
Diseases
Chronic myeloid leukemia (CML)
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Acute myeloid leukemia (AML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Rubinstein-Taybi syndrome
GWAS
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Age-related cognitive decline (language) (slope of z-scores) (
30954325
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
31959851
30929738
32296059
31619474
)
Asthma (adult onset) (
31036433
30929738
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Breast cancer (
31757997
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Esophageal cancer (
21642993
)
Esophageal squamous cell carcinoma (
25129146
)
Femoral neck length (
30888730
)
Gut microbiota alpha diversity (Chao1 index) (
33208821
)
HDL cholesterol (
30275531
)
Heel bone mineral density (
30598549
)
Height (
28552196
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
IgG N-glycosylation phenotypes (multivariate analysis) (
32128391
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Male-pattern baldness (
29146897
27182965
28196072
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) (
21829377
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Preeclampsia (
23551011
)
Psoriasis (
25903422
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (basophil) (
27863252
)
Autism spectrum disorder or schizophrenia (
28540026
)
Crohn's disease (
22936669
)
General risk tolerance (MTAG) (
30643258
)
Neuroticism (
29255261
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Schizophrenia (
28991256
25056061
29483656
)
Type 2 diabetes (
30297969
)
Interacting Genes
67 interacting genes:
AR
BAG3
BAG4
CBFA2T2
CBFA2T3
CBFB
CCND1
CCND2
CCND3
CCNK
CDK1
CDK6
CEBPA
CEBPB
COPRS
DNMT1
DTX2
DZIP3
ELF1
ELF2
ELF4
EP300
FAM222B
FBXO17
FOS
FOXP3
GCC1
HGS
HIPK1
HIPK2
IKZF1
IKZF3
JUN
KAT6A
KAT6B
MAPK1
MYOD1
NCOR1
NCOR2
NEDD4
NFKBID
OLIG3
PAX5
PRMT1
RBM14
RNF38
RNF44
SNRPC
SPEN
SPI1
SUV39H1
TAZ
TEAD2
TEAD4
TEKT5
TLE1
TLE2
TLE5
TRIM5
UBE2L6
UHRF2
UXT
VDR
VPS37C
WWP1
WWTR1
YAP1
374 interacting genes:
ABL1
ACSM5
ACTA2
ACTB
AHR
AKT1
ALKBH4
ALX1
APEX1
AR
ARHGDIA
ARNT
ARNTL
ARSF
ASCL1
ASH2L
ATF4
ATF5
ATR
AUTS2
BAG6
BCAS2
BCL3
BCL6
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDK1
CDK2
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLOCK
CNOT4
COPS2
COPS6
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DDX5
DECR2
DEK
DTX1
DUX4
E2F1
E2F5
EEF1A1
EEF2
EGR1
EID1
EID2
ELF3
ELK1
ELL
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO3
FOXP3
GAA
GABPA
GATA2
GATA4
GATA5
GATA6
GCKR
GLUL
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
H1-1
H1-3
H2AC20
H2AC21
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
H4C9
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HEMGN
HERC1
HIF1A
HMGB1
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
ILF2
ILF3
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KDM2A
KLF1
KLF13
KLF2
KLF4
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCL1
MCM2
MCM3
MCM3AP
MCM4
MCM5
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MGMT
MITF
MN1
MORF4L1
MPG
MRE11
MSH6
MSTO1
MTOR
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEIL2
NEUROD1
NFATC1
NFATC2
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR1I2
NR2F2
NR4A1
NUP98
NUPR1
OLIG2
ORC2
PAK2
PAX5
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POLI
POU3F2
PPARA
PPARD
PPARG
PPP2R5C
PRKCA
PRKCB
PRKCD
PRKDC
PRMT1
PROX1
PTMA
RACK1
RAD23A
RAD50
RAN
RB1
RBM14
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
RUVBL2
SATB1
SAV1
SELENOP
SENP3
SERTAD1
SET
SETD1A
SIRT1
SIRT2
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNAI1
SNIP1
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SREBF1
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUMO2
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBC
UBE2D1
UBE2I
UBQLN1
UBTF
USF2
VPS18
WDR59
WDR82
XRCC6
YWHAZ
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB49
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF148
ZNF76
ZRANB2
Entrez ID
861
2033
HPRD ID
01043
04078
Ensembl ID
ENSG00000159216
ENSG00000100393
Uniprot IDs
Q01196
Q09472
Q7Z6C1
PDB IDs
1CMO
1CO1
1E50
1H9D
1LJM
1L3E
1P4Q
2K8F
2MH0
2MZD
3BIY
3I3J
3IO2
3P57
3T92
4BHW
4PZR
4PZS
4PZT
5BT3
5KJ2
5LKT
5LKU
5LKX
5LKZ
5LPK
5LPM
5NU5
5XZC
6DS6
6FGN
6FGS
6GYR
6GYT
6K4N
6PF1
6PGU
6V8B
6V8K
6V8N
6V90
Enriched GO Terms of Interacting Partners
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