RUNX1 and IKZF1

Data Source:
BioGRID (pull down)

		RUNX1	IKZF1
Description		RUNX family transcription factor 1	IKAROS family zinc finger 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Core-binding Factor Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol Protein-containing Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regulation Of Plasminogen Activation Hemopoiesis Regulation Of Wnt Signaling Pathway Neuron Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Collagen Biosynthetic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Keratinocyte Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Regulation Of B Cell Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Tissue Regeneration Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Extracellular Matrix Organization Regulation Of Connective Tissue Replacement Regulation Of Bicellular Tight Junction Assembly	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cell Cycle Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs
Diseases		Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Acute myeloid leukemia (AML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 31036433 30929738) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) Gut microbiota alpha diversity (Chao1 index) ( 33208821) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 29146897 27182965 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)	Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 29296818) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 28334899) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) High density lipoprotein cholesterol levels ( 29403010) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 27863252 28017375 19862010) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010) Type 1 diabetes ( 25751624)
Interacting Genes		67 interacting genes: AR BAG3 BAG4 CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CCNK CDK1 CDK6 CEBPA CEBPB COPRS DNMT1 DTX2 DZIP3 ELF1 ELF2 ELF4 EP300 FAM222B FBXO17 FOS FOXP3 GCC1 HGS HIPK1 HIPK2 IKZF1 IKZF3 JUN KAT6A KAT6B MAPK1 MYOD1 NCOR1 NCOR2 NEDD4 NFKBID OLIG3 PAX5 PRMT1 RBM14 RNF38 RNF44 SNRPC SPEN SPI1 SUV39H1 TAZ TEAD2 TEAD4 TEKT5 TLE1 TLE2 TLE5 TRIM5 UBE2L6 UHRF2 UXT VDR VPS37C WWP1 WWTR1 YAP1	108 interacting genes: AEN ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 BARD1 BYSL C1orf109 C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CTBP2 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I WTAP ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587
Entrez ID		861	10320
HPRD ID		01043	04318
Ensembl ID		ENSG00000159216	ENSG00000185811
Uniprot IDs		Q01196	A0A2R8Y4D3 C9JTB0 Q13422 R9R4D9
PDB IDs		1CMO 1CO1 1E50 1H9D 1LJM	6H0F
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?