RUVBL1 and OFD1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RUVBL1	OFD1
Description		RuvB like AAA ATPase 1	OFD1 centriole and centriolar satellite protein
Image			No pdb structure
GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex	Extracellular Region Nucleus Centrosome Centriole Cytosol Cilium Microtubule Cytoskeleton Membrane Motile Cilium Centriolar Satellite Ciliary Basal Body
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding 5'-3' DNA Helicase Activity ADP Binding Cadherin Binding ATPase Binding	Protein Binding Identical Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding
	Biological Process	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Spermatogenesis Histone Acetylation Protein Deubiquitination DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Positive Regulation Of Telomerase RNA Localization To Cajal Body	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases			Oral-facial-digital syndrome 1 Joubert syndrome
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		20 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL LZTR1 MRGBP MYC NEDD4 OFD1 PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1 YY1 ZNHIT2	8 interacting genes: CCSER2 CEP126 EIF6 GPRASP1 LUC7L2 NME7 RUVBL1 S100A6
Entrez ID		8607	8481
HPRD ID		09143	02162
Ensembl ID		ENSG00000175792	ENSG00000046651
Uniprot IDs		A0A384MTR5 B3KRS7 E7ETR0 Q9Y265	A6NF31 E9KL37 O75665
PDB IDs		2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6K0R 6QI8 6QI9
Enriched GO Terms of Interacting Partners?
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