VPS13D and MADD

Data Source:
HPRD (two hybrid)

		VPS13D	MADD
Description		vacuolar protein sorting 13 homolog D	MAP kinase activating death domain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extrinsic Component Of Membrane Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Synapse
	Molecular Function		Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Protein Targeting To Vacuole Mitochondrion Organization Protein Retention In Golgi Apparatus Positive Regulation Of Mitophagy	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 19060911 25961943) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: MADD	10 interacting genes: NPDC1 PIDD1 POT1 PTPRN RB1CC1 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		55187	8567
HPRD ID		10593	04664
Ensembl ID		ENSG00000048707	ENSG00000110514
Uniprot IDs		Q5THJ4	A0A0A0MRB5 Q8WXG6
PDB IDs
Enriched GO Terms of Interacting Partners?
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