DIXDC1 and MAP3K4

Data Source:
HPRD (in vivo, in vitro)

		DIXDC1	MAP3K4
Description		DIX domain containing 1	mitogen-activated protein kinase kinase kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Focal Adhesion	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Protein Domain Specific Binding Gamma-tubulin Binding	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Differentiation Canonical Wnt Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Response To UV-C Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Interacting Genes		8 interacting genes: APP ATXN1 AXIN1 CDC5L MAP3K4 NDEL1 ULK2 ZDHHC17	26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ
Entrez ID		85458	4216
HPRD ID		16804	03886
Ensembl ID		ENSG00000150764	ENSG00000085511
Uniprot IDs		Q155Q3	Q9P1M2 Q9Y6R4
PDB IDs		3PZ7
Enriched GO Terms of Interacting Partners?
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