MAP3K4

Description		mitogen-activated protein kinase kinase kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Response To UV-C Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Novel Interacting Genes		1 novel interacting genes: EPHB4
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ
Entrez ID		4216
HPRD ID		03886
Ensembl ID		ENSG00000085511
Uniprot IDs		Q9P1M2 Q9Y6R4
PDB IDs
Enriched GO Terms of Interacting Partners?
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