ABCC2 and PDZD3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ABCC2	PDZD3
Description		ATP binding cassette subfamily C member 2	PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus Intracellular Canaliculus	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding
	Biological Process	Drug Transmembrane Transport Inflammatory Response Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Cellular Response To Drug Bile Acid Signaling Pathway Xenobiotic Catabolic Process Response To Estrogen Drug Export Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Response To Antineoplastic Agent Regulation Of Bile Acid Secretion Transport Across Blood-brain Barrier Benzylpenicillin Metabolic Process Response To 17alpha-ethynylestradiol Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS	Intestinal infectious diseases
Drugs		ATP Sulfinpyrazone
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748) Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8
Entrez ID		1244	79849
HPRD ID		03065	06191
Ensembl ID		ENSG00000023839	ENSG00000172367
Uniprot IDs		Q92887	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?
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