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YBX3 and CASP10
Data Source:
BioGRID
(pull down)
YBX3
CASP10
Description
Y-box binding protein 3
caspase 10
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Bicellular Tight Junction
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
CD95 Death-inducing Signaling Complex
Ripoptosome
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Nucleic Acid Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Small GTPase Binding
Polysome Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Spermatogenesis
Male Gonad Development
Fertilization
Regulation Of Gene Expression
Positive Regulation Of Organ Growth
Negative Regulation Of Skeletal Muscle Tissue Development
Negative Regulation Of Necroptotic Process
3'-UTR-mediated MRNA Stabilization
Cellular Response To Tumor Necrosis Factor
Cellular Hyperosmotic Response
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Cytoplasmic Translation
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Pathways
TP53 Regulates Transcription of Caspase Activators and Caspases
FasL/ CD95L signaling
TRAIL signaling
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Coronary artery disease (
33020668
)
Refractive error (
32231278
)
Basal cell carcinoma (
25855136
)
Chronic lymphocytic leukemia (
28165464
23770605
)
Chronic lymphocytic leukemia or rheumatoid arthritis (
31407831
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
84 interacting genes:
CDK4
CDK5
GSK3B
IL7R
MAPK1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NFYB
PCBP2
RALA
SRPK2
SYMPK
TJP1
VEGFA
30 interacting genes:
BFAR
BID
CASP1
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8
CASP8AP2
CASP9
CCAR1
CFLAR
DEDD
DEDD2
DSP
ECE2
FADD
NFKBIL1
OIP5
PHF20L1
POLR2A
PRDX6
RB1
RIOK3
RYBP
TNFRSF1A
TRAF1
XIAP
Entrez ID
8531
843
HPRD ID
10347
03458
Ensembl ID
ENSG00000060138
ENSG00000003400
Uniprot IDs
A0A024RAQ1
A0A024RAV4
P16989
A0A0S2Z3G5
A0A0S2Z3Z5
Q92851
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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