PPFIA4 and CAST

Data Source:
HPRD (in vitro, two hybrid)

		PPFIA4	CAST
Description		PTPRF interacting protein alpha 4	calpastatin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cell Surface Synapse Presynaptic Active Zone	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Protein Binding	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding
	Biological Process	Neurotransmitter Secretion Glutamate Secretion Synapse Organization	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Calcium Artenimol
Diseases
GWAS		Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 30061737 29892015) Early onset atrial fibrillation ( 28460022)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 29381148 26426971) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2	11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2
Entrez ID		8497	831
HPRD ID		16012	00233
Ensembl ID		ENSG00000143847	ENSG00000153113
Uniprot IDs		B3KN22 B4DIS5 O75335	B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs
Enriched GO Terms of Interacting Partners?
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