PPFIA4 and ERC2

Data Source:
BioGRID (two hybrid, pull down, two hybrid)
HPRD (in vitro, two hybrid)

		PPFIA4	ERC2
Description		PTPRF interacting protein alpha 4	ELKS/RAB6-interacting/CAST family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cell Surface Synapse Presynaptic Active Zone	Cytoskeleton Growth Cone Presynaptic Membrane Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Neurotransmitter Secretion Glutamate Secretion Synapse Organization	Neuromuscular Synaptic Transmission Synaptic Vesicle Priming Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 30061737 29892015) Early onset atrial fibrillation ( 28460022)	Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)
Interacting Genes		6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2	8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		8497	26059
HPRD ID		16012	10810
Ensembl ID		ENSG00000143847	ENSG00000187672
Uniprot IDs		B3KN22 B4DIS5 O75335	O15083
PDB IDs
Enriched GO Terms of Interacting Partners?
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