RAE1 and NUMA1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RAE1	NUMA1
Description		ribonucleic acid export 1	nuclear mitotic apparatus protein 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Host Cell Mitotic Spindle Pole	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Centrosome Spindle Cytosol Spindle Microtubule Cell Cortex Lateral Plasma Membrane Nuclear Matrix Extrinsic Component Of Plasma Membrane Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	Structural Molecule Activity Protein Binding Microtubule Binding Protein C-terminus Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Cell Cycle Viral Process Protein Sumoylation Viral Transcription Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
Drugs
Diseases
GWAS			Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		9 interacting genes: BDKRB1 BUB1 DDX24 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1	25 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A SUMO2 TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ
Entrez ID		8480	4926
HPRD ID		11939	01236
Ensembl ID		ENSG00000101146	ENSG00000137497
Uniprot IDs		P78406	A0A024R5M9 Q14980 Q3SYK8 Q4LE64
PDB IDs		3MMY 4OWR	3RO2 5GXW 6HC2 6QJA
Enriched GO Terms of Interacting Partners?
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