NUMA1 and ABRAXAS2

Data Source:
BioGRID (pull down)

		NUMA1	ABRAXAS2
Description		nuclear mitotic apparatus protein 1	abraxas 2, BRISC complex subunit
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GO Annotations	Cellular Component	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Centrosome Spindle Cytosol Spindle Microtubule Cell Cortex Lateral Plasma Membrane Nuclear Matrix Extrinsic Component Of Plasma Membrane Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone	Nucleus Cytoplasm Centrosome Cytosol Midbody Spindle Pole Centrosome Microtubule Minus-end BRISC Complex
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding Protein C-terminus Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Protein Deubiquitination Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly
Pathways		Recruitment of NuMA to mitotic centrosomes Mitotic Prophase	Metalloprotease DUBs
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Bone mineral content ( 31790847)
Interacting Genes		25 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A SUMO2 TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ	7 interacting genes: DCUN1D1 NUMA1 SHMT2 SMURF2 THAP5 UBC USP7
Entrez ID		4926	23172
HPRD ID		01236	13783
Ensembl ID		ENSG00000137497	ENSG00000165660
Uniprot IDs		A0A024R5M9 Q14980 Q3SYK8 Q4LE64	Q15018
PDB IDs		3RO2 5GXW 6HC2 6QJA	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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