PSRC1 and SRGN

Data Source:
BioGRID (two hybrid)

		PSRC1	SRGN
Description		proline and serine rich coiled-coil 1	serglycin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Microtubule Bundle Formation Mitotic Metaphase Plate Congression Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Mitotic Spindle Organization	Negative Regulation Of Cytokine Production Platelet Degranulation Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Blood protein levels ( 28240269) Cholesterol ( 31902109) Cholesterol, total ( 20686565) Coronary artery disease ( 32469254 29212778) Coronary heart disease ( 17634449 21378988) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) LDL cholesterol ( 18262040 18179892 18193043 18193044 19060906 19060910 21347282 20686565) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857) Low density lipoprotein cholesterol levels ( 30718733) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Progranulin levels ( 21087763 29186428) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Glycemic traits (pregnancy) ( 23903356) Hemoglobin levels ( 32327693)
Interacting Genes		4 interacting genes: APP ASB7 MAPRE3 SRGN	17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4
Entrez ID		84722	5552
HPRD ID		13127	01513
Ensembl ID		ENSG00000134222	ENSG00000122862
Uniprot IDs		A0A024R099 A8K0M8 Q6PGN9	P10124
PDB IDs
Enriched GO Terms of Interacting Partners?
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