IRS4 and CSNK1G2

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		IRS4	CSNK1G2
Description		insulin receptor substrate 4	casein kinase 1 gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Protein Autophosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		IRS-related events triggered by IGF1R	Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs			IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS			Body mass index ( 25673413) Coronary artery disease ( 29212778) Red cell distribution width ( 32888494 27863252)
Interacting Genes		22 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG	14 interacting genes: APP APPBP2 CERT1 DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 WDCP
Entrez ID		8471	1455
HPRD ID		04620	03738
Ensembl ID		ENSG00000133124	ENSG00000133275
Uniprot IDs		O14654	P78368
PDB IDs			2C47
Enriched GO Terms of Interacting Partners?
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