L3MBTL3 and PHF21A

Data Source:
BioGRID (two hybrid)

		L3MBTL3	PHF21A
Description		L3MBTL histone methyl-lysine binding protein 3	PHD finger protein 21A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Histone Deacetylase Complex Nucleoplasm DNA Repair Complex
	Molecular Function	Molecular_function Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding	DNA Binding Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Chromatin Organization Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Blood Coagulation
Pathways			HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758 27680694) Body mass index ( 25673413) Breast cancer ( 29059683 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Immature fraction of reticulocytes ( 32888494) Influenza A (H1N1) infection ( 26379185) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494 27863252) Mild influenza (H1N1) infection ( 26379185) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549 32154731) Weight ( 28552196) White blood cell count ( 32888494)	Adult body size ( 32376654) Adventurousness ( 30643258) Axial length ( 24144296) Height ( 29782485) Menarche (age at onset) ( 21102462 25231870) Refractive error ( 32231278) Triglyceride levels ( 32203549) Urate levels ( 31578528)
Interacting Genes		54 interacting genes: ASB6 BANP BYSL C1QTNF4 CRLF3 DEF6 DNMT1 FLAD1 FNDC3B GAS8 HSF2BP IL16 KANK2 KDM1A LMO4 LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MFAP1 MORF4L1 MORF4L2 NGB NRF1 NTAQ1 OAZ3 PDE6G PHC2 PHF21A PIK3R3 PLEKHF1 PLEKHF2 PLOD3 POLR2L PPP2CA PRKAA1 PRKAA2 RHOBTB3 SFMBT2 SNRPB SOX2 SP100 SPANXN2 SUFU SUMO1P1 TBC1D1 TCEANC THRA TRAF3IP3 TSTD2 TTC19 ZCWPW1 ZNF76	18 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20A HMG20B KDM1A KRT40 L3MBTL3 LPXN NUP62 RCOR1 SP3 TRAF1 ZYX
Entrez ID		84456	51317
HPRD ID		11222	10516
Ensembl ID		ENSG00000198945	ENSG00000135365
Uniprot IDs		Q96JM7	Q96BD5
PDB IDs		1WJQ 1WJS 3UT1 4FL6 4L59	2PUY 2YQL
Enriched GO Terms of Interacting Partners?
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