BRSK1 and CDC25C

Data Source:
HPRD (in vivo, in vitro)

		BRSK1	CDC25C
Description		BR serine/threonine kinase 1	cell division cycle 25C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Synaptic Vesicle Cell Junction Presynaptic Active Zone Distal Axon	Nucleus Nucleoplasm Cytoplasm Mitochondrial Intermembrane Space Cytosol Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Gamma-tubulin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding WW Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Neurotransmitter Secretion Axonogenesis Associative Learning Response To UV Response To Ionizing Radiation Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Synaptic Plasticity Regulation Of Axonogenesis Centrosome Duplication Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Clustering	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Mitotic Nuclear Division Spermatogenesis Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Peptidyl-tyrosine Dephosphorylation Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways			Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 26414677)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Intraocular pressure ( 31959993) Normal facial asymmetry (deformation magnitude) ( 30631343) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)
Interacting Genes		8 interacting genes: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A MAPT PAK1 WEE1	35 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 ERBB3 ERBB4 FHL1 HRAS LCK LMTK2 LZTS1 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ
Entrez ID		84446	995
HPRD ID		12533	01146
Ensembl ID		ENSG00000160469	ENSG00000158402
Uniprot IDs		Q8TDC3	B4DX61 P30307
PDB IDs			2OJX 3BZI 3OP3 5M35 5M36 5M37
Enriched GO Terms of Interacting Partners?
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