NSMAF and DCP1A

Data Source:
BioGRID (two hybrid, pull down)

		NSMAF	DCP1A
Description		neutral sphingomyelinase activation associated factor	decapping mRNA 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding Sphingomyelin Phosphodiesterase Activator Activity	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	Ceramide Metabolic Process Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Ceramide Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Protein Localization To Cytoplasmic Stress Granule
Pathways		TNFR1-mediated ceramide production	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Basophil count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		6 interacting genes: ACTB CD40 DCP1A DCP1B RACK1 TNFRSF1A	16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG
Entrez ID		8439	55802
HPRD ID		09117	06113
Ensembl ID		ENSG00000035681	ENSG00000272886
Uniprot IDs		Q92636	Q9NPI6
PDB IDs			2WX3 4B6H
Enriched GO Terms of Interacting Partners?
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