RECK and BMF

Data Source:
BioGRID (two hybrid)

		RECK	BMF
Description		reversion inducing cysteine rich protein with kazal motifs	Bcl2 modifying factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome	Acrosomal Vesicle Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway	Protein Binding
	Biological Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity	Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414 24292274) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		42 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704	26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54
Entrez ID		8434	90427
HPRD ID		05567	05881
Ensembl ID		ENSG00000122707	ENSG00000104081
Uniprot IDs		A8K9D8 O95980 Q6P9E2	Q96LC9
PDB IDs
Enriched GO Terms of Interacting Partners?
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