TMEM79 and ABO

Data Source:
BioGRID (two hybrid)

		TMEM79	ABO
Description		transmembrane protein 79	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Integral Component Of Membrane Trans-Golgi Network Membrane	Extracellular Region Golgi Apparatus Integral Component Of Membrane Vesicle Golgi Cisterna Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding Antigen Binding Glycoprotein-fucosylgalactoside Alpha-N-acetylgalactosaminyltransferase Activity Fucosylgalactoside 3-alpha-galactosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Manganese Ion Binding
	Biological Process	Epithelial Cell Maturation Hair Follicle Morphogenesis Cuticle Development Regulated Exocytosis Positive Regulation Of Epidermis Development Establishment Of Skin Barrier Cornification	Carbohydrate Metabolic Process Protein Glycosylation Protein Phosphopantetheinylation Lipid Glycosylation
Pathways			ABO blood group biosynthesis
Drugs			Uridine-Diphosphate-N-Acetylgalactosamine Uridine-5'-Diphosphate Galactose-uridine-5'-diphosphate 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,5-Diol 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol H TYPE II TRISACCHARIDE Human blood group H type 1 trisaccharide GALACTOSE GREASE BETA-METHYLLACTOSIDE octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranoside 4-AMINO-2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL 4-AMINO-2-OCTYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL octyl 3-deoxy-2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-xylo-hexopyranoside
Diseases
GWAS		Glycated hemoglobin levels ( 24647736 28898252 29170429) Mean corpuscular hemoglobin concentration ( 20139978)	Activated partial thromboplastin time ( 22703881 29403010) Adolescent idiopathic scoliosis ( 31417091 30395268) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29679657) Allergic rhinitis ( 30013184) Allergy ( 27182965) Angiotensin-converting enzyme activity ( 20066004) Asthma ( 32296059) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 29875488 28240269) Blood urea nitrogen levels ( 31152163 29403010) Breast cancer ( 29059683) C-reactive protein levels ( 30388399) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 24097068 25961943 20686565 26582766) Circulating fibroblast growth factor 23 levels ( 30217807) Clinical laboratory measurements ( 27897004) Coagulation factor levels ( 23267103) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Creatine kinase levels ( 29403010) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) Diastolic blood pressure ( 27841878 27618447) Diverticular disease ( 30177863) Duodenal ulcer ( 22387998) E-selectin levels ( 25147954 20147318) Elevated serum carcinoembryonic antigen levels ( 24941225) End-stage coagulation ( 23381943) Endothelial growth factor levels ( 25552591) Eosinophil counts ( 32888494) Epithelial ovarian cancer ( 25134534) Estimated glomerular filtration rate ( 31015462) Factor VIII levels ( 20231535 30586737) Fasting blood glucose ( 25631608) Gastric parietal cell autoantibody levels in type 1 diabetes ( 21829393) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Glycated hemoglobin levels ( 28898252) Glycine levels ( 31070104 30837465) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Graves' disease ( 21841780 23612905) Heart failure ( 31919418) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010 32888494 27863252 28017375) Hematological and biochemical traits ( 20139978) Hemoglobin ( 29403010 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494) High serum lipase activity ( 25028398) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers (multivariate analysis) ( 33110245) Insulin disposition index ( 23263489) Intake of total sugars ( 31005972) Interleukin-6 levels ( 32473944) Intraocular pressure ( 29617998 25173106 29785010 31959993 30054594 28073927 29235454) Iron status biomarkers (ferritin levels) ( 25352340) Ischemic stroke ( 29531354) Ischemic stroke (cardioembolic) ( 29531354) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 24097068 30275531 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 31087446 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Lipid traits ( 24386095) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 29403010) Low vWF levels ( 26486471) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Malaria ( 22895189 23717212 31844061) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 20139978 27863252) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Metabolic traits ( 21886157) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Myocardial infarction ( 26343387) Myocardial infarction in coronary artery disease ( 21239051) Neurological blood protein biomarker levels ( 31320639) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Optic cup area ( 28073927) Pancreatic cancer ( 29422604 19648918 26098869 25086665) Peripheral artery disease ( 31285632) Phytosterol levels ( 20529992) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Platelet reactivity measurement (collagen-ADP) ( 31262040) Platelet reactivity measurement (collagen-epinephrine) ( 31262040) Plateletcrit ( 32888494 27863252) Protein biomarker ( 23056639) Protein quantitative trait loci ( 18464913) Pulse pressure ( 27841878) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Serum alkaline phosphatase levels ( 24094242 31666285 29403010 32084209) Serum cancer antigen 15.3 levels ( 31666285) Serum carcinoembryonic antigen levels ( 31666285) Serum lipase activity ( 25028398) Serum thyroid-stimulating hormone levels ( 25436638) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485) Soluble E-selectin levels ( 31217265 19729612) Soluble ICAM-1 ( 21533024 31217265 18604267) Soluble levels of adhesion molecules ( 20167578) Soluble VCAM-1 levels ( 31217265) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thrombosis ( 26908601) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 28334899 29403010 30275531) Triglyceride levels ( 32154731) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Tumor biomarkers ( 23300138) Type 2 diabetes ( 28566273 30054458 29358691 30297969 32499647) Urinary metabolites (H-NMR features) ( 24586186) Venous thromboembolism ( 21980494 23650146 19278955 25772935 28373160 31420334 22672568 31676865) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826) White blood cell count ( 32888494 27863252)
Interacting Genes		36 interacting genes: ABO AMIGO1 ANKRD46 APOD ARL13B BRICD5 CLEC7A COQ9 CPLX4 CYB5R3 FAM209A FNDC9 GIMAP1 GPRC5D LDLRAD1 LPAR3 PELI2 PLN PLP2 PVR RNF8 RPRM SEC22A SERP1 SFTPC SLN TEX264 TMEM100 TMEM14C TMEM254 TMEM97 TMPRSS2 TMPRSS4 TNMD TRAM1L1 ZCCHC12	2 interacting genes: GRAMD2B TMEM79
Entrez ID		84283	28
HPRD ID		17481	05821
Ensembl ID		ENSG00000163472	ENSG00000175164
Uniprot IDs		Q9BSE2	A0A089QDC1 P16442
PDB IDs			1LZ0 1LZ7 1LZI 1LZJ 1R7T 1R7U 1R7V 1R7X 1R7Y 1R80 1R81 1R82 1WSZ 1WT0 1WT1 1WT2 1WT3 1XZ6 1ZHJ 1ZI1 1ZI3 1ZI4 1ZI5 1ZIZ 1ZJ0 1ZJ1 1ZJ2 1ZJ3 1ZJO 1ZJP 2A8U 2A8W 2I7B 2O1F 2O1G 2O1H 2PGV 2PGY 2RIT 2RIX 2RIY 2RIZ 2RJ0 2RJ1 2RJ4 2RJ5 2RJ6 2RJ7 2RJ8 2RJ9 2Y7A 3I0C 3I0D 3I0E 3I0F 3I0G 3I0H 3I0I 3I0J 3I0K 3I0L 3IOH 3IOI 3IOJ 3SX3 3SX5 3SX7 3SX8 3SXA 3SXB 3SXC 3SXD 3SXE 3SXG 3U0X 3U0Y 3V0L 3V0M 3V0N 3V0O 3V0P 3V0Q 3ZGF 3ZGG 4C2S 4FQW 4FRA 4FRB 4FRD 4FRE 4FRH 4FRL 4FRM 4FRO 4FRP 4FRQ 4GBP 4KC1 4KC2 4KC4 4KXO 4Y62 4Y63 4Y64 5BXC 5C1G 5C1H 5C1L 5C36 5C38 5C3A 5C3B 5C3D 5C47 5C48 5C49 5C4B 5C4C 5C4D 5C4E 5C4F 5C8R 5CMF 5CMG 5CMH 5CMI 5CMJ 5CQL 5CQM 5CQN 5CQO 5CQP 5M79 5M7A 5M7B 5M7C 5M7D 5TJK 5TJL 5TJN 5TJO 6BJI 6BJJ 6BJK 6BJL 6BJM 6GWY 6GWZ 6GX0 6GX1 6GX2
Enriched GO Terms of Interacting Partners?
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