PRADC1 and DBH

Data Source:
HPRD (in vitro)

		PRADC1	DBH
Description		protease associated domain containing 1	dopamine beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Transport Vesicle Membrane Secretory Granule Membrane Centriolar Satellite Chromaffin Granule Lumen Secretory Granule Lumen Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Synapse
	Molecular Function	Protein Binding	Catalytic Activity Dopamine Beta-monooxygenase Activity Copper Ion Binding Protein Binding L-ascorbic Acid Binding
	Biological Process		Blood Vessel Remodeling Response To Amphetamine Leukocyte Mediated Immunity Octopamine Biosynthetic Process Chemical Synaptic Transmission Memory Locomotory Behavior Visual Learning Regulation Of Cell Population Proliferation Homoiothermy Dopamine Catabolic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Glucose Homeostasis Fear Response Maternal Behavior Positive Regulation Of Vasoconstriction Behavioral Response To Ethanol Response To Pain Leukocyte Migration Positive Regulation Of Cold-induced Thermogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Catecholamine biosynthesis
Drugs			Ascorbic acid Disulfiram Dopamine
Diseases			Dopamine beta-hydroxylase deficiency; Norepinephrine deficiency; Noradrenaline deficiency
GWAS			Diastolic blood pressure ( 28739976 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean arterial pressure ( 27618448) Nicotine dependence ( 28972577) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smoking behavior ( 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking cessation ( 30617275) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27618452 30578418)
Interacting Genes		3 interacting genes: DBH VAC14 XRN1	3 interacting genes: NBPF19 NOTCH2NLA PRADC1
Entrez ID		84279	1621
HPRD ID		12815	01963
Ensembl ID		ENSG00000135617	ENSG00000123454
Uniprot IDs		Q9BSG0	P09172
PDB IDs			4ZEL
Enriched GO Terms of Interacting Partners?
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