CAMKK1 and CAMK4

Data Source:
HPRD (in vitro)

		CAMKK1	CAMK4
Description		calcium/calmodulin dependent protein kinase kinase 1	calcium/calmodulin dependent protein kinase IV
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity	Adaptive Immune Response Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Peptidyl-serine Phosphorylation Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs		Fostamatinib	K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Smoking behavior ( 19247474)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569)
Interacting Genes		9 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 PRKAA1 SGK1 YWHAG	10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		84254	814
HPRD ID		13000	07169
Ensembl ID		ENSG00000004660	ENSG00000152495
Uniprot IDs		J3KPJ3 Q8N5S9	Q16566
PDB IDs		6CCF 6CD6	2W4O
Enriched GO Terms of Interacting Partners?
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