CAMKK1 and CAMK1D

Data Source:
HPRD (in vitro)

		CAMKK1	CAMK1D
Description		calcium/calmodulin dependent protein kinase kinase 1	calcium/calmodulin dependent protein kinase ID
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Intracellular Anatomical Structure Nucleus Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity	Inflammatory Response Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Regulation Of Dendrite Development Positive Regulation Of Respiratory Burst Regulation Of Granulocyte Chemotaxis Positive Regulation Of Neutrophil Chemotaxis
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib	N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE Fostamatinib
Diseases
GWAS		Smoking behavior ( 19247474)	Anorexia nervosa ( 23568457) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Bipolar disorder ( 31043756) Body mass index ( 28892062) Borderline personality disorder ( 28632202) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery aneurysm in Kawasaki disease ( 27171184) Eating disorders ( 23568457) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Headache ( 29397368) Height ( 31562340) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) QT interval (drug interaction) ( 23459443) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Tea consumption ( 31046077) Type 2 diabetes ( 22885922 18372903 26961502 20862305 29358691 30297969 26818947 32499647 30718926)
Interacting Genes		9 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 PRKAA1 SGK1 YWHAG	12 interacting genes: APP ASAH1 BNIP3L CAMKK1 CDC25A CUL3 GMFG LRRK2 NEDD4 NEDD4L POT1 TNFSF13
Entrez ID		84254	57118
HPRD ID		13000	06409
Ensembl ID		ENSG00000004660	ENSG00000183049
Uniprot IDs		J3KPJ3 Q8N5S9	Q5SQQ7 Q8IU85
PDB IDs		6CCF 6CD6	2JC6 6QP5 6T28 6T29 6T6F
Enriched GO Terms of Interacting Partners?
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