SGIP1 and EPS15L1

Data Source:
BioGRID (pull down)

		SGIP1	EPS15L1
Description		SH3GL interacting endocytic adaptor 1	epidermal growth factor receptor pathway substrate 15 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Clathrin-coated Vesicle	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Clathrin Coat Of Coated Pit
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding SH3 Domain Binding	Calcium Ion Binding Protein Binding Cadherin Binding
	Biological Process	Response To Dietary Excess Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior	Endocytosis Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)	Basophil count ( 32888494) Body size at age 10 ( 32376654) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 22190364 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) White blood cell count ( 32888494 27863252 21738480) White matter integrity ( 23218918)
Interacting Genes		5 interacting genes: APP DAB2 EPS15 EPS15L1 ITSN1	15 interacting genes: AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 ITSN1 ITSN2 LRRC7 NDC80 SGIP1 STON2 TRAPPC2 TRAPPC2B UBC
Entrez ID		84251	58513
HPRD ID		10910	09445
Ensembl ID		ENSG00000118473	ENSG00000127527
Uniprot IDs		Q9BQI5	A0A024R7G6 Q9UBC2
PDB IDs		5AWR 5AWS 5AWT 5AWU 6A9Y
Enriched GO Terms of Interacting Partners?
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