EPS15L1 and AGFG2

Data Source:
BioGRID (genetic interference)
HPRD (in vitro)

		EPS15L1	AGFG2
Description		epidermal growth factor receptor pathway substrate 15 like 1	ArfGAP with FG repeats 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Clathrin Coat Of Coated Pit	Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Cadherin Binding	Molecular_function GTPase Activator Activity Metal Ion Binding
	Biological Process	Endocytosis Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Biological_process Positive Regulation Of GTPase Activity
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Basophil count ( 32888494) Body size at age 10 ( 32376654) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 22190364 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) White blood cell count ( 32888494 27863252 21738480) White matter integrity ( 23218918)	Brain morphology (MOSTest) ( 32665545) Hematocrit ( 27863252) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 ITSN1 ITSN2 LRRC7 NDC80 SGIP1 STON2 TRAPPC2 TRAPPC2B UBC	4 interacting genes: APP EPS15 EPS15L1 ITSN1
Entrez ID		58513	3268
HPRD ID		09445	04932
Ensembl ID		ENSG00000127527	ENSG00000106351
Uniprot IDs		A0A024R7G6 Q9UBC2	A4D2D6 O95081
PDB IDs
Enriched GO Terms of Interacting Partners?
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