SGIP1 and USP16

Data Source:
HPRD (in vivo)

		SGIP1	USP16
Description		SH3GL interacting endocytic adaptor 1	ubiquitin specific peptidase 16
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Clathrin-coated Vesicle	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding SH3 Domain Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding
	Biological Process	Response To Dietary Excess Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Ub-specific processing proteases
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: APP DAB2 EPS15 EPS15L1 ITSN1	15 interacting genes: CALM1 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 PLK1 PTOV1 TTK UBC UBD
Entrez ID		84251	10600
HPRD ID		10910	06881
Ensembl ID		ENSG00000118473	ENSG00000156256
Uniprot IDs		Q9BQI5	Q9Y5T5
PDB IDs		5AWR 5AWS 5AWT 5AWU 6A9Y	2I50
Enriched GO Terms of Interacting Partners?
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