ZNRF3 and C3orf52

Data Source:
BioGRID (two hybrid)

		ZNRF3	C3orf52
Description		zinc and ring finger 3	chromosome 3 open reading frame 52
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Wnt Receptor Catabolic Process Limb Development Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 27618448 30487518) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 29403010 27618448 30487518) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 29422604 25086665) Systolic blood pressure ( 27618448 30578418) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		7 interacting genes: C3orf52 GFI1B HSPB1 RSPO1 RSPO2 RSPO3 UBE2N	72 interacting genes: ADGRG3 AGER AHNAK2 AMIGO1 AQP6 ATP1B4 BIK CCL21 CCL26 CD33 CHST13 CLDN7 CLEC10A CNMD CPLX4 CREB3 DEXI ERGIC3 ERP29 ESAM FAM209A FFAR2 FNDC9 FOLH1 FUT3 GJA8 GJB1 GOLM2 GORAB HHLA2 HSD17B13 KEL KIR2DL3 KLRC1 LEUTX LHFPL5 LMNA LRRC25 MFF MGST2 MGST3 MRGPRX3 MUC1 NCR3LG1 NEMP1 NPDC1 NSG2 PVR QPCTL REEP3 RNF150 SAR1A SGTA SIGLECL1 SLC10A2 SLC16A2 SLC23A2 SLC39A2 SPRING1 ST6GALNAC3 STOM SYNE4 TIMMDC1 TMEM179B TMEM237 TMEM45B TMEM52B TMEM80 TMPRSS2 TMX2 UPK2 ZNRF3
Entrez ID		84133	79669
HPRD ID		11737	08018
Ensembl ID		ENSG00000183579	ENSG00000114529
Uniprot IDs		A0A024R1J1 Q9ULT6	Q5BVD1
PDB IDs
Enriched GO Terms of Interacting Partners?
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