RAB22A and EEA1

Data Source:
HPRD (two hybrid, in vitro)

		RAB22A	EEA1
Description		RAB22A, member RAS oncogene family	early endosome antigen 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Early Endosome Late Endosome Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Exosome	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Regulation Of Vesicle Size	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport
Pathways		RAB geranylgeranylation	Toll Like Receptor 9 (TLR9) Cascade
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Metabolite levels ( 23823483) Nickel levels ( 26025379)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)
Interacting Genes		7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2	13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		57403	8411
HPRD ID		06696	05460
Ensembl ID		ENSG00000124209	ENSG00000102189
Uniprot IDs		Q9UL26	Q15075
PDB IDs			1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?
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