PRAM1 and BCAR1

Data Source:
BioGRID (two hybrid)

		PRAM1	BCAR1
Description		PML-RARA regulated adaptor molecule 1	BCAR1 scaffold protein, Cas family member
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Protein-containing Complex	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Axon
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization
Pathways			Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Coronary artery disease ( 29212778) Height ( 18391951)	Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)
Interacting Genes		25 interacting genes: A2M ABI2 APOE APP BCAR1 CCDC57 CDC37 FXR1 FXR2 GOLGA2 KRT40 LCP2 LYN MAST1 MXD1 NEDD9 NEK6 PSEN1 RNF32 SH3RF1 SKAP1 SKAP2 TP53BP2 TRIM27 UBE2E2	65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FAM102A FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ
Entrez ID		84106	9564
HPRD ID		05926	04248
Ensembl ID		ENSG00000133246	ENSG00000050820
Uniprot IDs		Q96QH2	B3KWE2 P56945
PDB IDs			1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?
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