USP44 and H2BC1

Data Source:
BioGRID (enzymatic study)

		USP44	H2BC1
Description		ubiquitin specific peptidase 44	H2B clustered histone 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Extrinsic Component Of Plasma Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding	Molecular_function DNA Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Cell Cycle Chromosome Segregation Protein Deubiquitination Protein Phosphopantetheinylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin Protein Ligase Activity	Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Protein Ubiquitination Plasminogen Activation Spermatogenesis, Exchange Of Chromosomal Proteins Positive Regulation Of Binding Mononuclear Cell Migration
Pathways		Ub-specific processing proteases	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Breast size ( 27182965) C-reactive protein levels ( 30388399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Response to anti-depressant treatment in major depressive disorder ( 22041458) Type 2 diabetes ( 30297969)
Interacting Genes		1 interacting genes: H2BC1	8 interacting genes: ANP32B APP CCNA1 DNTTIP2 H2AC20 HDAC3 SET USP44
Entrez ID		84101	255626
HPRD ID		15636	11024
Ensembl ID		ENSG00000136014	ENSG00000146047
Uniprot IDs		A0A024RBD7 Q9H0E7	Q96A08
PDB IDs			3WKJ 5GSU 5GT3 6BIY
Enriched GO Terms of Interacting Partners?
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