ARL6 and PROS1

Data Source:
BioGRID (affinity chromatography technology)

		ARL6	PROS1
Description		ADP ribosylation factor like GTPase 6	protein S
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GO Annotations	Cellular Component	Cytoplasm Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Visual Perception Wnt Signaling Pathway Vesicle-mediated Transport Melanosome Transport Protein Polymerization Cilium Assembly Protein Localization To Cilium	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration
Pathways		BBSome-mediated cargo-targeting to cilium	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs			Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases		Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)	Inherited thrombophilia
GWAS		Male infertility ( 19478329)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B	10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3
Entrez ID		84100	5627
HPRD ID		10588	01473
Ensembl ID		ENSG00000113966	ENSG00000184500
Uniprot IDs		Q9H0F7	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs		2H57	1Z6C
Enriched GO Terms of Interacting Partners?
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