SPRTN and POLD3

Data Source:
BioGRID (pull down)

		SPRTN	POLD3
Description		SprT-like N-terminal domain	DNA polymerase delta 3, accessory subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Speck	Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Metalloendopeptidase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Proteolysis Cellular Response To DNA Damage Stimulus Response To UV Protein Autoprocessing Translesion Synthesis Positive Regulation Of Protein Ubiquitination Error-free Translesion Synthesis Protein-DNA Covalent Cross-linking Repair	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Translesion Synthesis by POLH	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494)	Colorectal cancer ( 22634755 25990418 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29691431 29313844) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)
Interacting Genes		3 interacting genes: POLD3 RNF11 UBC	8 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1 SPRTN
Entrez ID		83932	10714
HPRD ID		13164	11446
Ensembl ID		ENSG00000010072	ENSG00000077514
Uniprot IDs		A0A024R3U2 Q9H040	A0A024R5M8 Q15054
PDB IDs		5IY4 6MDW 6MDX	1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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