CDCA7 and DYNC1I2

Data Source:
HPRD (in vivo)

		CDCA7	DYNC1I2
Description		cell division cycle associated 7	dynein cytoplasmic 1 intermediate chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle
	Molecular Function	Protein Binding	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Apoptotic Process Regulation Of Cell Population Proliferation	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Regulation Of G2/M Transition Of Mitotic Cell Cycle Transport Along Microtubule Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood pressure measurement (low sodium intervention) ( 24165912) Breast cancer ( 29059683 23535729) End-stage renal disease in Type 1 diabetics ( 24029427) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Male-pattern baldness ( 29146897 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) Prostate cancer ( 29892016) Sensation seeking ( 30718321)	Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		1 interacting genes: APP	8 interacting genes: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1
Entrez ID		83879	1781
HPRD ID		09874	04512
Ensembl ID		ENSG00000144354	ENSG00000077380
Uniprot IDs		Q9BWT1	A0A140VKE9 B4DPZ3 Q13409
PDB IDs			5JPW 6F1T 6F1U 6F1Z 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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