KRTAP4-12 and CBX2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KRTAP4-12	CBX2
Description		keratin associated protein 4-12	chromobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Keratin Filament	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		152 interacting genes: ADAM12 ADAMTSL4 ALPP AQP1 ATG12 ATN1 AXIN1 BAG4 BAHD1 BEX2 C10orf62 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CDX2 CHCHD3 CHIC2 CHRD CLCNKA CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 CYSRT1 DBF4B DLK2 EIF4E2 ELOA2 FAM107A FAM27E3 FAM76B FBXL18 FBXO34 FBXW5 FCHO1 FUCA2 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 IGSF8 ILF3 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP5-1 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NLA NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP POU4F2 PRKAB2 PRKAG1 PRR13 PTPMT1 QPRT R3HDM2 RERE RPS28 SHFL SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY1 SPRY2 TAP1 TBC1D16 TBC1D23 TGM1 THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF414 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF497 ZNF581 ZNF638 ZNF655 ZNF696 ZNF764 ZNF837 ZSCAN26	25 interacting genes: BOLL CYSRT1 DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 PCGF2 PHC2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RNF2 RYBP TRIM55 TRIM63
Entrez ID		83755	84733
HPRD ID		13941	14397
Ensembl ID		ENSG00000213416	ENSG00000173894
Uniprot IDs		Q9BQ66	Q14781
PDB IDs			2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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